Gjorgje Blayer was born in Stara Pazova (Vojvodina, then part of Austria-Hungary) on 29 October 1908, as the second child of Isidor and Aranka Blayer (maiden name Adam). His older brother Mirko was executed by a firing squad in 1941 in Jajinci (Belgrade). Jelena, Mirko's wife, and their five-year-old son Ivan were killed in the Ustasha camp in Jasenovac, and Aranka, Gjorgje’s mother, in Auschwitz in 1944. The younger brother, Zoran, was deported together with the Macedonian Jews and killed in Treblinka in March 1943. Of the approximately 70 members of the wider family, only Gjorgje and his cousin Alice Freund survived World War II.

During World War I (1914-1918), Isidor, along with other men from that area, was hiding in Frushka Gora so as not to be recruited into the Austro-Hungarian army. Aranka was left alone to run their small grocery shop while Mirko and Gjorgje were going to school. Before the end of the war, Zoran was born, but after a few years, Isidor died and the family moved to Novi Sad.

In 1922, 14-year-old Gjorgje and two-year-old Mirko left for Belgrade. A year later, Gjorgje became a dental technician and Mirko an electrician. They soon joined the trade union movement and took part in strikes and demonstrations to improve the rights and working conditions of the workers. Because of these activities, Gjorgje became a candidate for member of the Communist Party in 1927, but he was also included in the police files as an opponent of the regime.

Blayer came to Macedonia for the first time when serving his military service in Shtip, from 1929 to 1931. Due to his political activity, the authorities forbade him to live in Belgrade and Novi Sad, so, following a party directive, he returned to Shtip the following year and got a job as a dental technician. He was deported from Shtip to Valandovo and then to Kichevo, and in 1937 he arrived in Skopje, where he was arrested, sentenced to six months in prison, then deported from Macedonia, and then moved to Kosovo.

There he was accepted as a member of the KPJ in 1937. In the beginning he organized the activities of the party cell in the village of Shtrpce, and in 1939 he was appointed secretary of the KPJ for the Nerodim area. As a "suspicious person", he was repeatedly expelled from place to place, but stayed in Uroshevac and Prizren for the longest time, where he met his future wife Jelena Hadzi Peric, whom he married in February 1940.

At the end of the year, Gjorgje and Jelena came to Belgrade, joining his brothers Mirko and Zoran, who was agronomy student. After the bombing of Belgrade on 6 April 1941 and the beginning of the German occupation, rigorous anti-Jewish laws were introduced. At the same time, the Communist Party began preparations for an uprising and issued a directive to its members: "Everyone on their battle posts!" For Gjorgje, that battle post was Macedonia and he, together with his wife and brother Zoran, arrived in Skopje on 9 June 1941 with forged documents.

Here he opened a dental office and became actively involved in the People's Liberation Movement. His dental office and apartment were shelters for his fellow party members and anti-fascists, where in addition to health services, support was also provided to the illegals and partisans. When a bust happened in the party organization, the Bulgarian occupying police arrested him on 23 September 1942. During the investigation, Blayer often changed his statements, and on 13 November 1942 he was sentenced to "only" five years in prison for lack of solid evidence.

During the deportation of the Macedonian Jews, Blayer was in the Central Prison in the Kale in Skopje (when the prison was damaged in January 1944 during the Allied bombing of Skopje, the prisoners were transferred to the Idrizovo prison). His 25-year-old brother Zoran was taken to the Monopoly and then deported and executed at the Nazi Treblinka camp. Gjorgje's wife, Jelena, was also arrested along with him and taken to the Monopoly in the raid. However, when, based on precise German documents, the Bulgarian authorities identified her as a Serb, she was released and immediately sent to Gorna Dzumaja (Bulgaria).

During his imprisonment, Blayer ran a prison dental practice through which the political prisoners kept in touch with the illegals in the city and the partisans in the area. He was one of the organizers of the escape of political prisoners from Idrizovo on 28 August 1944, including 19 young Bulgarian Jewish-Communists. Joining, together with his wife Jelena, in the ranks of the 42nd Brigade of the National Liberation Army and POM (Partisan Detachments of Macedonia), Blayer organized and became the manager of the partisan hospital in Gorno Vranovci, in the region of Veles, which was the first military hospital in the new state. After the liberation in November 1944, the hospital was moved to Skopje and Gjorgje remained at its helm for another two years, until his demobilization in a rank of captain.

Meanwhile, on 26 December 1945, Gjorgje Blayer was elected President of the Macedonian-Jewish Religious Community. Regular, necessary relations with the new state government were immediately established for the purpose of supporting the admission of the surviving and returning Jews in Skopje and in Macedonia; return of ownership over the socially-owned facilities of the Jewish religious community (synagogue, Jewish club, school and cemeteries); for recording of the Jews genocide data; mediation for transit of the Jewish returnees to Greece and, through Macedonia, of the immigrants from Europe to Israel.

Due to the public criticism of the situation in the country and the opposition to the Yugoslav state policy towards the Inform Bureau, Gjorgje Blayer was expelled in 1948 from the Communist Party and the Union of Reserve Military Veterans. Because he did not retracted from those views, he was detained in October 1950 and, after a three-month investigation, was given an "administrative measure" (actually a sentence), which he served on Goli Otok until 3 January 1953.

His 18-month-old son Mirko, died during that time because, and as a child of "Informbureau man", no one dared to treat him with pneumonia. Two and a half years after the return of Gjorgje from Goli Otok, his wife Jelena also died at the age of 40.

After returning from Goli Otok and taking a break for several years, Gjorgje Blayer resumed his work for the Jewish community as its secretary and president for several terms until his death. Among his most significant engagements were the relocation of the old Jewish cemetery from Vodno to a new complex in Butel, the renovation of the municipal building after the November 1962 floods, and organization of the construction of the current building of the Jewish municipality in Skopje.

In the meantime, he has worked as a teacher at the secondary school of dentistry, head of the dental ambulance “Kisela Voda” and head of the Dental Health Department at “Replek” company.

In 1958 he was awarded the "Partisan Commemoration Plaque 1941" and was re-admitted to the Communist Party of Macedonia.

Gjorgji Blayer died on 19 March 1970.